참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Azobisisobutyronitrile | HCID 6547 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 3-Bromo-4-methylbenzoic acid | HCID 82130 | — |
| 용매 | (Trifluoromethyl)benzene | HCID 7368 | — |
| 생성물 | 3-bromo-4-(bromomethyl)benzoic Acid | HCID 11616314 | 60% |
반응 단계
To a solution of 3-bromo-4-methylbenzoic acid (1.0 equiv.) and AIBN (0.05 equiv.) in trifluorotoluene (0.28 M) was added NBS (1.1 equiv.). The mixture was heated at 90° C. overnight. The reaction mixture was partitioned between EtOAc and H2O. The organic layer was washed with NaCl(sat.), dried over MgSO4, filtered, concentrated to yield 3-bromo-4-(bromomethyl)benzoic acid in 60% yield. LC/MS (m/z)=294.8 (MH+), Rt=0.80 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09242969B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_01 |
|---|
| ORD ID | ord-a5833216af294f4aa238714c4ebbf9dd |
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| 출처 메모 | uspto-grants-2016_01 |
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