Sulfuric Acid → 4-(Bromomethyl)benzamide

반응식

[Br:1][CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1.[OH:11]S(O)(=O)=O>>[Br:1][CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]([NH2:8])=[O:11])=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 1118Sulfuric Acid

HCID 869964-(Bromomethyl)benzonitrile

생성물 1

HCID 5842164-(Bromomethyl)benzamide

실험 절차

Stirred the solution of 4-(bromomethyl)benzonitrile (1.5 g) in cocn. H2SO4 at 100° C. for 3-4 h. After completion of the reaction, the reaction mass was quenched in ice and filtered to afford 0.900 of desired product. 1H NMR (400 MHz, DMSO d6): δ 4.71 (s, 2H), 7.26 (br s, 1H), 7.49 (d, J=7.8 Hz, 2H), 7.82 (d, J=7.8 Hz, 2H), 7.89 (br s, 1H); MS (m/z): 214.36 (M+H)+.

후처리

customAfter completion of the reaction
customthe reaction mass was quenched in ice
filtrationfiltered

출처 및 근거

ORD 기록: ord-ec4dace15ed347c7a111d2c945e33d13
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09439890B2

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