Morpholine → 4-(4-(Benzyloxy)-6-chloropyridin-2-yl)morpholine

HRID 594093

반응식

HRID 594093 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[C:13](Cl)[N:12]=[C:11]([Cl:16])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>CN1C(=O)CCC1>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([Cl:16])[N:12]=[C:13]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 582090464-(Benzyloxy)-2,6-dichloropyridine

생성물 1

HCID 904099474-(4-(Benzyloxy)-6-chloropyridin-2-yl)morpholine

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
130 °C

실험 절차

A mixture of 4-(benzyloxy)-2,6-dichloropyridine (1.0 equiv.) and morpholine (1.2 equiv.) in NMP (2 M) were heated to 130° C. for 1 h in the microwave. The reaction mixture was partitioned between water and EtOAc. The organic phase was washed with brine and dried over sodium sulfate. The solution was concentrated and dried under vacuo to give crude 4-(4-(benzyloxy)-6-chloropyridin-2-yl)morpholine and was used in the next step without further purification. LCMS (m/z) (M+H)=305.0, Rt=1.10 min.

후처리

  1. customThe reaction mixture was partitioned between water and EtOAc
  2. washThe organic phase was washed with brine
  3. dry with materialdried over sodium sulfate
  4. concentrationThe solution was concentrated
  5. customdried under vacuo

출처 및 근거

ORD 기록
ord-c2eedfd2ac7642efb0746d80526589d0
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242969B2

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