4-Fluorobenzenesulfonyl chloride → HCID 89875926, 화합물

HRID 594117

반응식

HRID 594117 반응식
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([NH2:10])=[N:8][CH:9]=1)([CH3:3])[CH3:2].[F:11][C:12]1[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1>N1C=CC=CC=1>[F:11][C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH:10][C:7]2[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][N:8]=2)(=[O:20])=[O:19])=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 179858055-(Propan-2-yl)pyridin-2-amine

생성물 1

HCID 89875926HCID 89875926, 화합물수율 66.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

5-isopropylpyridin-2-amine (300 mg, 2.20 mmol) and 4-fluorobenzene-1-sulfonyl chloride (557 mg, 2.86 mmol) were dissolved in pyridine (3 mL) and left to stand overnight. The reaction mixture was concentrated in vacuo and the crude product extracted to the organic phase of an acidic workup between ethyl acetate and 5% citric acid. The organic phase was passed through a hydrophobic frit and concentrated in vacuo to give the title compound (430 mg). LCMS (2 min, formic) Rt 0.90 min, m/z (ES+) 295 (M+H).

후처리

  1. waitleft
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. extractionthe crude product extracted to the organic phase of an acidic workup between ethyl acetate and 5% citric acid
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-cb801e81b9cb49548a2316c7451a05f4
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242972B2

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