Styrene-4-sulfonyl chloride → HCID 89876040, 화합물

HRID 594141

반응식

HRID 594141 반응식
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([NH2:10])=[N:8][CH:9]=1)([CH3:3])[CH3:2].[CH:11]([C:13]1[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1)=[CH2:12]>N1C=CC=CC=1>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][S:19]([C:16]2[CH:17]=[CH:18][C:13]([CH:11]=[CH2:12])=[CH:14][CH:15]=2)(=[O:21])=[O:20])=[N:8][CH:9]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 9855777Styrene-4-sulfonyl chlorideHCID 179858055-(Propan-2-yl)pyridin-2-amine

생성물 1

HCID 89876040HCID 89876040, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 5-isopropylpyridin-2-amine (400 mg, 2.94 mmol) in pyridine (5 mL), stirred at room temperature, was added 4-vinylbenzene-1-sulfonyl chloride (760 mg, 3.75 mmol). The reaction mixture was stirred for 30 minutes then stood overnight. The solvent was evaporated in vacuo and the crude sample purified by normal phase chromatography on silica (Si) (0-50% ethyl acetate-cyclohexane gradient). The appropriate fractions were combined and evaporated in vacuo to give the title product, 670 mg, as an off-white solid. LCMS (2 min, formic) Rt 0.98 min, m/z (ES+) 303 (M+H).

후처리

  1. waitthen stood overnight
  2. customThe solvent was evaporated in vacuo
  3. customthe crude sample purified by normal phase chromatography on silica (Si) (0-50% ethyl acetate-cyclohexane gradient)
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-01faa48f2f634de2a97d950c83df31df
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242972B2

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