(2-Chloro-5-(pyridin-2-yl)phenyl)methanol → 2-Chloro-5-(pyridin-2-yl)benzaldehyde

HRID 594221노트

반응식

HRID 594221 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:4][C:3]=1[CH2:14][OH:15]>C1COCC1.O=[Mn]=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:4][C:3]=1[CH:14]=[O:15]

참가 물질

4

반응물 1

HCID 69083854(2-Chloro-5-(pyridin-2-yl)phenyl)methanol

생성물 1

HCID 866956092-Chloro-5-(pyridin-2-yl)benzaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of (2-chloro-5-(pyridin-2-yl)phenyl)methanol (129 mg; 0.72 mmol) in anh. THF (7 ml) was treated with MnO2 (975 mg; 11.22 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 6.5 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with THF. The filtrate was concentrated to dryness under reduced pressure giving 2-chloro-5-(pyridin-2-yl)benzaldehyde as a yellow oil. LC-MS (conditions A): tR=0.43 min.; no ionisation.

후처리

  1. customThe resulting reaction mixture
  2. filtrationwas then filtered over celite
  3. washthe separated solids were washed with THF
  4. concentrationThe filtrate was concentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-e499c14df9794d05a477fcdfd2438064
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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