(3-(5-Methylthiazol-2-yl)phenyl)methanol → 3-(5-Methylthiazol-2-yl)benzaldehyde
반응식
[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:8]=[C:9]([CH2:13][OH:14])[CH:10]=[CH:11][CH:12]=2)=[N:4][CH:3]=1>C(Cl)Cl.O=[Mn]=O>[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:8]=[C:9]([CH:10]=[CH:11][CH:12]=2)[CH:13]=[O:14])=[N:4][CH:3]=1참가 물질
4
실험 절차
A solution of (3-(5-methylthiazol-2-yl)phenyl)methanol (210 mg; 1.02 mmol) in anh. DCM (8 ml) was treated with MnO2 (1.334 g; 15.34 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 1.5 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 3-(5-methylthiazol-2-yl)benzaldehyde as a colorless solid. LC-MS (conditions A): tR=0.72 min.; [M+H]+: 203.99 g/mol.
후처리
- customThe resulting reaction mixture
- filtrationwas then filtered over celite
- washthe separated solids were washed with DCM
- concentrationThe filtrate was concentrated to dryness under reduced pressure
출처 및 근거
- ORD 기록
- ord-fe539833c462414f83844ae0aa2e46db
- 출처 데이터셋
- uspto-grants-2016_01
- 특허 번호
- US09242970B2
반응 노트
불러오는 중…