(3-(2H-1,2,3-triazol-2-yl)phenyl)methanol → 3-(2H-1,2,3-triazol-2-yl)benzaldehyde

HRID 594249노트

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HRID 594249 반응식
[N:1]1[N:2]([C:6]2[CH:7]=[C:8]([CH2:12][OH:13])[CH:9]=[CH:10][CH:11]=2)[N:3]=[CH:4][CH:5]=1>C(Cl)Cl.O=[Mn]=O>[N:1]1[N:2]([C:6]2[CH:7]=[C:8]([CH:9]=[CH:10][CH:11]=2)[CH:12]=[O:13])[N:3]=[CH:4][CH:5]=1

참가 물질

4

반응물 1

HCID 53488009(3-(2H-1,2,3-triazol-2-yl)phenyl)methanol

생성물 1

HCID 834815283-(2H-1,2,3-triazol-2-yl)benzaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6344Dichloromethane용매

실험 절차

A solution of (3-(2H-1,2,3-triazol-2-yl)phenyl)methanol (425 mg; 2.42 mmol) in anh. DCM (24 ml) was treated with MnO2 (3.165 g; 36.41 mmol), and the resulting mixture was stirred at rt, under nitrogen, for 1.5 h. The resulting reaction mixture was then filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 3-(2H-1,2,3-triazol-2-yl)benzaldehyde as a pale yellow solid. LC-MS (conditions A): tR=0.63 min.; no ionisation.

후처리

  1. customThe resulting reaction mixture
  2. filtrationwas then filtered over celite
  3. washthe separated solids were washed with DCM
  4. concentrationThe filtrate was concentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-198db9f03f2b4a04a5a8423a71ed396e
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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