(2-(1H-Pyrazol-1-YL)pyridin-4-YL)methanol → 2-(1H-pyrazol-1-yl)isonicotinaldehyde

HRID 594255노트

반응식

HRID 594255 반응식
[N:1]1([C:6]2[CH:11]=[C:10]([CH2:12][OH:13])[CH:9]=[CH:8][N:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1>ClCCCl.O=[Mn]=O>[N:1]1([C:6]2[CH:11]=[C:10]([CH:9]=[CH:8][N:7]=2)[CH:12]=[O:13])[CH:5]=[CH:4][CH:3]=[N:2]1

참가 물질

4

반응물 1

HCID 61256684(2-(1H-Pyrazol-1-YL)pyridin-4-YL)methanol

생성물 1

HCID 866956132-(1H-pyrazol-1-yl)isonicotinaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 111,2-Dichloroethane용매

실험 절차

A solution of (2-(1H-pyrazol-1-yl)pyridin-4-yl)methanol (217 mg; 1.23 mmol) in anh. DCE (4 ml) was treated with MnO2 (861 mg; 9.91 mmol), and the resulting mixture was stirred at reflux, under nitrogen, for 1.5 h. After cooling to rt, the resulting reaction mixture was filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 2-(1H-pyrazol-1-yl)isonicotinaldehyde as a colorless solid. LC-MS (conditions C): tR=0.70 min.; [M+H]+: 173.76 g/mol.

후처리

  1. temperatureat reflux, under nitrogen, for 1.5 h
  2. customthe resulting reaction mixture
  3. filtrationwas filtered over celite
  4. washthe separated solids were washed with DCM
  5. concentrationThe filtrate was concentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-cc8bd2ae05df457fad3193ded08c17cb
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

반응 노트

불러오는 중…