(2-(4-Methylthiazol-2-yl)pyridin-4-yl)methanol → 2-(4-Methylthiazol-2-yl)isonicotinaldehyde
반응식
[CH3:1][C:2]1[N:3]=[C:4]([C:7]2[CH:12]=[C:11]([CH2:13][OH:14])[CH:10]=[CH:9][N:8]=2)[S:5][CH:6]=1>ClCCCl.O=[Mn]=O>[CH3:1][C:2]1[N:3]=[C:4]([C:7]2[CH:12]=[C:11]([CH:10]=[CH:9][N:8]=2)[CH:13]=[O:14])[S:5][CH:6]=1참가 물질
4
실험 절차
A solution of (2-(4-methylthiazol-2-yl)pyridin-4-yl)methanol (750 mg; 3.64 mmol) in anh. DCE (40 ml) was treated with MnO2 (1.581 g; 18.20 mmol), and the resulting mixture was heated at reflux, under nitrogen, for 1.5 h. After cooling to rt, the resulting reaction mixture was filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 2-(4-methylthiazol-2-yl)isonicotinaldehyde as an off-white solid. LC-MS (conditions A): tR=0.64 min.; [M+H]+: 205.04 g/mol.
후처리
- temperaturethe resulting mixture was heated
- temperatureat reflux, under nitrogen, for 1.5 h
- customthe resulting reaction mixture
- filtrationwas filtered over celite
- washthe separated solids were washed with DCM
- concentrationThe filtrate was concentrated to dryness under reduced pressure
출처 및 근거
- ORD 기록
- ord-984b2cad35f944ea8766820f9c0eb8f0
- 출처 데이터셋
- uspto-grants-2016_01
- 특허 번호
- US09242970B2
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