(2-(5-Methylthiazol-2-yl)pyridin-4-yl)methanol → 2-(5-Methylthiazol-2-yl)isonicotinaldehyde

HRID 594296노트

반응식

HRID 594296 반응식
[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:12]=[C:11]([CH2:13][OH:14])[CH:10]=[CH:9][N:8]=2)=[N:4][CH:3]=1>ClCCCl.O=[Mn]=O>[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:12]=[C:11]([CH:10]=[CH:9][N:8]=2)[CH:13]=[O:14])=[N:4][CH:3]=1

참가 물질

4

반응물 1

HCID 69084104(2-(5-Methylthiazol-2-yl)pyridin-4-yl)methanol

생성물 1

HCID 866956202-(5-Methylthiazol-2-yl)isonicotinaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 111,2-Dichloroethane용매

실험 절차

A solution of (2-(5-methylthiazol-2-yl)pyridin-4-yl)methanol (1.910 g; 9.26 mmol) in anh. DCE (80 ml) was treated with MnO2 (4.025 g; 46.30 mmol), and the resulting mixture was heated at reflux, under nitrogen, for 1.5 h. After cooling to rt, the resulting reaction mixture was filtered over celite, and the separated solids were washed with DCM. The filtrate was concentrated to dryness under reduced pressure giving 2-(5-methylthiazol-2-yl)isonicotinaldehyde as an off-white solid. LC-MS (conditions A): tR=0.65 min.; [M+H]+: 205.35 g/mol.

후처리

  1. temperaturethe resulting mixture was heated
  2. temperatureat reflux, under nitrogen, for 1.5 h
  3. customthe resulting reaction mixture
  4. filtrationwas filtered over celite
  5. washthe separated solids were washed with DCM
  6. concentrationThe filtrate was concentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-b54819fc474c4e8cace0e9fd001506fd
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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