Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 5-fluoro-3-methyl-1H-indole-2-propanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate | HCID 19794669 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-fluoro-3-methyl-1H-indole-2-propanoic acid | HCID 22141166 | 102% |
반응 단계
A mixture of isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate (0.42 g),1N sodiumhydroxide (6.3 ml) and methanol (20 ml) are stirred at room temperature for 4 hours. The reaction mixture is poured into water, washed with methylene chloride, acidified with 1N HCl and extracted with methylene chloride. The organic layer, dried and evaporated, affords 0.36 g of 5-fluoro-3-methyl-1H-indole-2-propanoic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05246957 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-ce2094f8a0e9499fa6e6eca4f823126b |
| 출처 메모 | uspto-grants-1993_09 |