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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 594423생성일: 2026년 10월 25일

Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate → 1-((5-Chloro-6-(difluoromethoxy)pyridin-3-yl)methyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

https://huagongshe.com/reaction/594423

반응식

참여 물질

역할이름HCID투입량
반응물Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoateHCID 69082713—
반응물3-Pyridinecarboxaldehyde, 5-chloro-6-(difluoromethoxy)-HCID 86695614—
생성물1-((5-Chloro-6-(difluoromethoxy)pyridin-3-yl)methyl)-6-(2,6-dimethoxyphenyl)piperidin-2-oneHCID 69081953—

반응 단계

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with 5-chloro-6-(difluoromethoxy)-nicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.88 min.; [M+H]+: 427.28 g/mol.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09242970B2
출처 데이터셋uspto-grants-2016_01
ORD IDord-6901464eb63f45489d7dd09189ad5d72
출처 메모uspto-grants-2016_01