3-Morpholinobenzaldehyde → 6-(2,6-Dimethoxyphenyl)-1-(3-morpholinobenzyl)piperidin-2-one

HRID 594435

반응식

HRID 594435 반응식
[NH2:1][CH:2]([C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]([O:8]C)=O.[O:20]1[CH2:25][CH2:24][N:23]([C:26]2[CH:27]=[C:28]([CH:31]=[CH:32][CH:33]=2)[CH:29]=O)[CH2:22][CH2:21]1>>[CH3:19][O:18][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]([O:16][CH3:17])[C:10]=1[CH:2]1[N:1]([CH2:29][C:28]2[CH:31]=[CH:32][CH:33]=[C:26]([N:23]3[CH2:24][CH2:25][O:20][CH2:21][CH2:22]3)[CH:27]=2)[C:6](=[O:8])[CH2:5][CH2:4][CH2:3]1

참가 물질

3

반응물 2

HCID 71645843-MorpholinobenzaldehydeHCID 69082713Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate

생성물 1

HCID 690857586-(2,6-Dimethoxyphenyl)-1-(3-morpholinobenzyl)piperidin-2-one

실험 절차

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with commercially available 3-morpholinobenzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.72 min.; [M+H]+: 411.21 g/mol.

후처리

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

출처 및 근거

ORD 기록
ord-ccd0b69497574118b3a54a7737d4294f
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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