1-Phenyl-1H-pyrazole-4-carbaldehyde → 6-(2,6-dimethoxyphenyl)-1-((1-phenyl-1H-pyrazol-4-yl)methyl)piperidin-2-one

HRID 594444

반응식

HRID 594444 반응식
[NH2:1][CH:2]([C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]([O:8]C)=O.[C:20]1([N:26]2[CH:30]=[C:29]([CH:31]=O)[CH:28]=[N:27]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH3:19][O:18][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]([O:16][CH3:17])[C:10]=1[CH:2]1[N:1]([CH2:31][C:29]2[CH:28]=[N:27][N:26]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:30]=2)[C:6](=[O:8])[CH2:5][CH2:4][CH2:3]1

참가 물질

3

반응물 2

HCID 9520891-Phenyl-1H-pyrazole-4-carbaldehydeHCID 69082713Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate

생성물 1

HCID 690821986-(2,6-dimethoxyphenyl)-1-((1-phenyl-1H-pyrazol-4-yl)methyl)piperidin-2-one

실험 절차

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with commercially available 1-phenyl-1H-pyrazole-4-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.80 min.; [M+H]+: 392.36 g/mol.

후처리

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

출처 및 근거

ORD 기록
ord-2bdb7a61a138445787b4670a75bdc984
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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