3-Phenylbenzaldehyde → 1-([1,1'-Biphenyl]-3-ylmethyl)-6-(2,4-dimethoxypyridin-3-yl)piperidin-2-one

HRID 594478노트

반응식

HRID 594478 반응식
[NH2:1][CH:2]([C:10]1[C:11]([O:18][CH3:19])=[N:12][CH:13]=[CH:14][C:15]=1[O:16][CH3:17])[CH2:3][CH2:4][CH2:5][C:6]([O:8]C)=O.[C:20]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:25]=[CH:24][CH:23]=[C:22]([CH:26]=O)[CH:21]=1>>[C:20]1([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][N:1]2[CH:2]([C:10]3[C:11]([O:18][CH3:19])=[N:12][CH:13]=[CH:14][C:15]=3[O:16][CH3:17])[CH2:3][CH2:4][CH2:5][C:6]2=[O:8])[CH:21]=1

참가 물질

3

반응물 2

HCID 1210533-PhenylbenzaldehydeHCID 69082421Methyl 5-amino-5-(2,4-dimethoxypyridin-3-yl)pentanoate

생성물 1

HCID 690837601-([1,1'-Biphenyl]-3-ylmethyl)-6-(2,4-dimethoxypyridin-3-yl)piperidin-2-one

실험 절차

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,4-dimethoxypyridin-3-yl)pentanoate with commercially available [1,1′-biphenyl]-3-carbaldehyde. Subsequent purification by preparative HPLC the target compound. LC-MS (conditions A): tR=0.83 min.; [M+H]+: 403.34 g/mol.

후처리

  1. customPrepared
  2. customSubsequent purification by preparative HPLC the target compound

출처 및 근거

ORD 기록
ord-65409439c3764d409cf8c7bcd4541b0b
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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