Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 4-Fluorophenylhydrazine hydrochloride | HCID 69981 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Ethyl 4-oxohexanoate | HCID 12271528 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate | HCID 19794669 | — |
반응 단계
A mixture of 1-(4-fluorophenyl)hydrazine hydrochloride (1.03 g), ethyl 4-oxo-hexanoate (1.0 g), 2-propanol (25 ml) and H2SO4 is refluxed under nitrogen for 9 hours. After cooling the mixture is poured into a aqueous solution of NaHCO3, extracted with AcOEt and evaporated to dryness to yield 1.45 g of isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05246957 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-7032a768e4ff40098e40773662a0af2f |
| 출처 메모 | uspto-grants-1993_09 |