Methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate → 1-((2-(1H-pyrazol-1-yl)pyridin-4-yl)methyl)-7-(2,6-dimethoxyphenyl)azepan-2-one

HRID 594521노트

반응식

HRID 594521 반응식
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=O.[N:21]1([C:26]2[CH:27]=[C:28]([CH:31]=[CH:32][N:33]=2)[CH:29]=O)[CH:25]=[CH:24][CH:23]=[N:22]1>>[N:21]1([C:26]2[CH:27]=[C:28]([CH2:29][N:1]3[CH:2]([C:11]4[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=4[O:19][CH3:20])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]3=[O:9])[CH:31]=[CH:32][N:33]=2)[CH:25]=[CH:24][CH:23]=[N:22]1

참가 물질

3

반응물 2

HCID 69082587Methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoateHCID 866956132-(1H-pyrazol-1-yl)isonicotinaldehyde

생성물 1

HCID 690845381-((2-(1H-pyrazol-1-yl)pyridin-4-yl)methyl)-7-(2,6-dimethoxyphenyl)azepan-2-one

실험 절차

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate with 2-(1H-pyrazol-1-yl)isonicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.83 min.; [M+H]+: 407.11 g/mol.

후처리

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

출처 및 근거

ORD 기록
ord-933d876c156c49c6977df1716f8227a4
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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