2-Methyl-1,3-benzothiazole-6-carbaldehyde → 5-(2,6-Dimethoxyphenyl)-3-methyl-1-((2-methylbenzo[d]thiazol-6-yl)methyl)pyrrolidin-2-one
반응식
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH:4]([CH3:10])[C:5]([O:7]CC)=O.[CH3:21][C:22]1[S:23][C:24]2[CH:30]=[C:29]([CH:31]=O)[CH:28]=[CH:27][C:25]=2[N:26]=1>>[CH3:18][O:17][C:16]1[CH:15]=[CH:14][CH:13]=[C:12]([O:19][CH3:20])[C:11]=1[CH:2]1[N:1]([CH2:31][C:29]2[CH:28]=[CH:27][C:25]3[N:26]=[C:22]([CH3:21])[S:23][C:24]=3[CH:30]=2)[C:5](=[O:7])[CH:4]([CH3:10])[CH2:3]1참가 물질
3
실험 절차
Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with 2-methylbenzo[d]thiazole-6-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.78 min.; [M+H]+: 397.02 g/mol.
후처리
- customPrepared
- customSubsequent purification by preparative HPLC
- customafforded the target compound