1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 6-(2,6-Dimethoxyphenyl)-4-methyl-1-(4-(trifluoromethoxy)benzyl)piperidin-2-one

HRID 594591노트

반응식

HRID 594591 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[NH:16][C:15](=[O:17])[CH2:14][CH:13]([CH3:18])[CH2:12]1.Br[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[N:16]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28]([F:29])([F:30])[F:31])=[CH:23][CH:22]=2)[C:15](=[O:17])[CH2:14][CH:13]([CH3:18])[CH2:12]1

참가 물질

3

반응물 2

HCID 1427851-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 690854016-(2,6-Dimethoxyphenyl)-4-methylpiperidin-2-one

생성물 1

HCID 763322386-(2,6-Dimethoxyphenyl)-4-methyl-1-(4-(trifluoromethoxy)benzyl)piperidin-2-one

실험 절차

Prepared according to the described general procedure 4 (GP4) by reaction of 6-(2,6-dimethoxyphenyl)-4-methylpiperidin-2-one with commercially available 1-(bromomethyl)-4-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions D): tR=1.13 min.; [M+H]+: 423.91 g/mol.

후처리

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

출처 및 근거

ORD 기록
ord-d2191863bd74423ea8d3c8a7c5b21edf
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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