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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 594614생성일: 2026년 10월 26일

1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 5-(2,6-Dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

https://huagongshe.com/reaction/594614

반응식

참여 물질

역할이름HCID투입량
반응물1-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 142785—
반응물5-(2,6-Dimethoxyphenyl)pyrrolidin-2-oneHCID 69080911—
생성물5-(2,6-Dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-oneHCID 69085010—

반응 단계

Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)pyrrolidin-2-one with commercially available 1-(bromomethyl)-4-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.80 min.; [M+H]+: 396.00 g/mol.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09242970B2
출처 데이터셋uspto-grants-2016_01
ORD IDord-377e750005df4e2db93d27fc07a67fc4
출처 메모uspto-grants-2016_01