Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Fluorobenzyl bromide → 5-(2,6-Dimethoxyphenyl)-1-(4-fluorobenzyl)pyrrolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Fluorobenzyl bromide | HCID 68021 | — |
| 반응물 | 5-(2,6-Dimethoxyphenyl)pyrrolidin-2-one | HCID 69080911 | — |
| 생성물 | 5-(2,6-Dimethoxyphenyl)-1-(4-fluorobenzyl)pyrrolidin-2-one | HCID 69085756 | — |
반응 단계
Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)pyrrolidin-2-one with commercially available 1-(bromomethyl)-4-fluorobenzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.71 min.; [M+H]+: 330.24 g/mol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09242970B2 |
| 출처 데이터셋 | uspto-grants-2016_01 |
| ORD ID | ord-12aed9d020874c699f39475e1f7b47d3 |
| 출처 메모 | uspto-grants-2016_01 |