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Water → 6-(3-Chloro-2,6-dimethoxyphenyl)-1-(3-(2-methylthiazol-4-yl)benzyl)piperidin-2-one

HRID 594664
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HRID 594664 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH:11]1[N:16]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]3[N:25]=[C:26]([CH3:29])[S:27][CH:28]=3)[CH:19]=2)[C:15](=[O:30])[CH2:14][CH2:13][CH2:12]1.C1C(=O)N([Cl:38])C(=O)C1.O.CCOC(C)=O>CN(C=O)C>[Cl:38][C:8]1[C:3]([O:2][CH3:1])=[C:4]([CH:11]2[N:16]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([C:24]4[N:25]=[C:26]([CH3:29])[S:27][CH:28]=4)[CH:19]=3)[C:15](=[O:30])[CH2:14][CH2:13][CH2:12]2)[C:5]([O:9][CH3:10])=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 31398ChlorosuccinimideHCID 690825166-(2,6-Dimethoxyphenyl)-1-(3-(2-methylthiazol-4-yl)benzyl)piperidin-2-one

생성물 1

HCID 690826986-(3-Chloro-2,6-dimethoxyphenyl)-1-(3-(2-methylthiazol-4-yl)benzyl)piperidin-2-one

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

A mixture of 6-(2,6-dimethoxyphenyl)-1-(3-(2-methylthiazol-4-yl)benzyl)piperidin-2-one (60 mg; 0.14 mmol; compound corresponding to example 16), and NCS (21 mg; 0.15 mmol) in anh. DMF (1.5 ml) was stirred at rt, under nitrogen, for 24 h. Water (5 ml), and AcOEt (10 ml) were added, and the separated organic layer was washed with brine (5 ml), dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure.

후처리

  1. washthe separated organic layer was washed with brine (5 ml)
  2. dry with materialdried over anh. MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-7b85db242eb948ff849adcee61e6aa43
출처 데이터셋
uspto-grants-2016_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09242970B2

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