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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 594703생성일: 2026년 10월 26일

3-Fluoro-4-(trifluoromethoxy)benzaldehyde → 5-(2-Ethoxy-6-fluorophenyl)-1-(3-fluoro-4-(trifluoromethoxy)benzyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594703

반응식

참여 물질

역할이름HCID투입량
반응물3-Fluoro-4-(trifluoromethoxy)benzaldehydeHCID 2783358—
반응물Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoateHCID 69083532—
생성물5-(2-Ethoxy-6-fluorophenyl)-1-(3-fluoro-4-(trifluoromethoxy)benzyl)-3-methylpyrrolidin-2-oneHCID 69083660—

반응 단계

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 3-fluoro-4-(trifluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.98 min.; [M+H]+: 429.97 g/mol.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09242970B2
출처 데이터셋uspto-grants-2016_01
ORD IDord-fd19b08752704f89a2aeb0827674ba71
출처 메모uspto-grants-2016_01