p-(Difluoromethoxy)benzaldehyde → 1-(4-(Difluoromethoxy)benzyl)-5-(2-ethoxy-6-fluorophenyl)-3-methylpyrrolidin-2-one

HRID 594704

반응식

HRID 594704 반응식
[NH2:1][CH:2]([C:11]1[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=1[O:18][CH2:19][CH3:20])[CH2:3][CH:4]([CH3:10])[C:5]([O:7]CC)=O.[F:21][CH:22]([F:32])[O:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=1>>[F:21][CH:22]([F:32])[O:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][N:1]2[CH:2]([C:11]3[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=3[O:18][CH2:19][CH3:20])[CH2:3][CH:4]([CH3:10])[C:5]2=[O:7])=[CH:26][CH:25]=1

참가 물질

3

반응물 2

HCID 2736986p-(Difluoromethoxy)benzaldehydeHCID 69083532Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate

생성물 1

HCID 690820351-(4-(Difluoromethoxy)benzyl)-5-(2-ethoxy-6-fluorophenyl)-3-methylpyrrolidin-2-one

실험 절차

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 4-(difluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.90 min.; [M+H]+: 394.01 g/mol.

후처리

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

출처 및 근거

ORD 기록
ord-e44d54d9cf79472cb5027f15945a4fb6
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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