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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 594706생성일: 2026년 10월 26일

3-Chloro-4-(difluoromethoxy)benzaldehyde → 1-(3-Chloro-4-(difluoromethoxy)benzyl)-5-(2-ethoxy-6-fluorophenyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594706

반응식

참여 물질

역할이름HCID투입량
반응물3-Chloro-4-(difluoromethoxy)benzaldehydeHCID 20274088—
반응물Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoateHCID 69083532—
생성물1-(3-Chloro-4-(difluoromethoxy)benzyl)-5-(2-ethoxy-6-fluorophenyl)-3-methylpyrrolidin-2-oneHCID 69082779—

반응 단계

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 3-chloro-4-(difluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.93 min.; [M+H]+: 427.96 g/mol.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09242970B2
출처 데이터셋uspto-grants-2016_01
ORD IDord-42a34b3d53744cb981fb2b31410d6e3f
출처 메모uspto-grants-2016_01