2-(4-Methylphenyl)-1,3-thiazole-4-carbaldehyde → 5-(2-Ethoxy-6-fluorophenyl)-3-methyl-1-((2-(p-tolyl)thiazol-4-yl)methyl)pyrrolidin-2-one

HRID 594714노트

반응식

HRID 594714 반응식
[NH2:1][CH:2]([C:11]1[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=1[O:18][CH2:19][CH3:20])[CH2:3][CH:4]([CH3:10])[C:5]([O:7]CC)=O.[C:21]1([CH3:34])[CH:26]=[CH:25][C:24]([C:27]2[S:28][CH:29]=[C:30]([CH:32]=O)[N:31]=2)=[CH:23][CH:22]=1>>[CH2:19]([O:18][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]([F:17])[C:11]=1[CH:2]1[N:1]([CH2:32][C:30]2[N:31]=[C:27]([C:24]3[CH:25]=[CH:26][C:21]([CH3:34])=[CH:22][CH:23]=3)[S:28][CH:29]=2)[C:5](=[O:7])[CH:4]([CH3:10])[CH2:3]1)[CH3:20]

참가 물질

3

반응물 2

HCID 140235712-(4-Methylphenyl)-1,3-thiazole-4-carbaldehydeHCID 69083532Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate

생성물 1

HCID 690852275-(2-Ethoxy-6-fluorophenyl)-3-methyl-1-((2-(p-tolyl)thiazol-4-yl)methyl)pyrrolidin-2-one

실험 절차

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 2-(p-tolyl)thiazole-4-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.98 min.; [M+H]+: 425.01 g/mol.

후처리

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

출처 및 근거

ORD 기록
ord-a87c500005c24c66acebb32d50865278
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242970B2

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