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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 594730생성일: 2026년 10월 26일

p-(Difluoromethoxy)benzaldehyde → 1-(4-(Difluoromethoxy)benzyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594730

반응식

참여 물질

역할이름HCID투입량
반응물p-(Difluoromethoxy)benzaldehydeHCID 2736986—
반응물Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoateHCID 69085588—
생성물1-(4-(Difluoromethoxy)benzyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-oneHCID 69083449—

반응 단계

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with commercially available 4-(difluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.86 min.; [M+H]+: 391.78 g/mol.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09242970B2
출처 데이터셋uspto-grants-2016_01
ORD IDord-c0a1dc422846477c96b49f7f5e41cbd3
출처 메모uspto-grants-2016_01