Formic Acid → N-(1,3-dihydro-2-benzofuran-5-yl)formamide

반응식

[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[CH2:3][O:2]1.[CH:11](O)=[O:12]>>[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH:10][CH:11]=[O:12])=[CH:9][C:4]=2[CH2:3][O:2]1

참가 물질

반응물 2

HCID 284Formic Acid

HCID 124453391,3-Dihydro-2-benzofuran-5-amine

생성물 1

HCID 118597990N-(1,3-dihydro-2-benzofuran-5-yl)formamide수율 69%

실험 절차

1,3-Dihydro-2-benzofuran-5-amine (300 mg, 2.2 mmol) was added to HCOOH (10 mL), and the reaction was stirred at reflux overnight. The reaction was concentrated, basified to pH=8 with sat Na2CO3, and extracted with EtOAc. Organics were washed with brine, dried (Na2SO4), and concentrated to give 250 mg (69%) of N-(1,3-dihydro-2-benzofuran-5-yl)formamide as a yellow oil.

후처리

temperatureat reflux overnight
concentrationThe reaction was concentrated
extractionextracted with EtOAc
washOrganics were washed with brine
dry with materialdried (Na2SO4)
concentrationconcentrated

출처 및 근거

ORD 기록: ord-2a377d8236184c4cb1970cc1c652a1d1
출처 데이터셋: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09242968B2

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