1-(4-Nitrophenyl)azetidine → Benzenamine,4-(1-azetidinyl)-

HRID 594814노트

반응식

HRID 594814 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O>CCO.[Pd]>[N:10]1([C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)[CH2:11][CH2:12][CH2:13]1

참가 물질

4

반응물 1

HCID 5917181-(4-Nitrophenyl)azetidine

생성물 1

HCID 45078992Benzenamine,4-(1-azetidinyl)-수율 100.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

10% Pd/C (70 mg) was added to a solution of 1-(4-nitrophenyl)azetidine (0.7 g, 3.9 mmol) in EtOH (15 mL) at r.t. under N2. After stirring under 50 psi H2 overnight, the reaction mixture was filtered through Celite and concentrated to give 580 mg (99%) of the title compound as a brown oil. [M+H] Calc'd for C9H12N2, 149. Found, 149.

후처리

  1. filtrationthe reaction mixture was filtered through Celite
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1fb2d44776e144a893e9528fd2c78119
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242968B2

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