alpha-Bromo-o-fluorotoluene → HCID 67112034, 화합물

HRID 594971노트

반응식

HRID 594971 반응식
BrCC1C=CC=CC=1F.ClC1N=C2NN=CC2=CN=1.Cl[C:21]1[N:26]=[C:25]2[N:27]([CH2:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[F:37])[N:28]=[CH:29][C:24]2=[CH:23][N:22]=1.C[N:39]1[CH:43]=[C:42]([NH2:44])[CH:41]=[N:40]1>>[F:37][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=1[CH2:30][N:27]1[C:25]2=[N:26][C:21]([NH:44][C:42]3[CH:43]=[N:39][NH:40][CH:41]=3)=[N:22][CH:23]=[C:24]2[CH:29]=[N:28]1

참가 물질

5

반응물 4

HCID 67968alpha-Bromo-o-fluorotolueneHCID 47709901-methyl-1H-pyrazol-4-amineHCID 529112546-chloro-1H-pyrazolo[3,4-d]pyrimidineHCID 86671734HCID 86671734, 화합물

생성물 1

HCID 67112034HCID 67112034, 화합물

실험 절차

The following compound was made according to the procedures in Example 1 (Step ii) using 1-(bromomethyl)-2-fluorobenzene and 6-chloro-1H-pyrazolo[3,4-d]pyrimidine followed by Example 1 (Step i) using 6-chloro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidine and 1-methyl-1H-pyrazol-4-amine:

출처 및 근거

ORD 기록
ord-10bbf89f5322491a8b0f9f553667ff99
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242987B2

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