2-Methyl-3-(4-morpholinyl)benzoic acid → HCID 67112254, 화합물

HRID 594990노트

반응식

HRID 594990 반응식
[CH3:1][C:2]1[C:10]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5]>C1COCC1>[CH3:1][C:2]1[C:10]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][OH:5]

참가 물질

3

반응물 1

HCID 71484262-Methyl-3-(4-morpholinyl)benzoic acid

생성물 1

HCID 67112254HCID 67112254, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

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온도
0 °C

실험 절차

2-methyl-3-morpholinobenzoic acid (0.5 g, 2.26 mmol) was dissolved in dry THF (12 mL) under Nitrogen and the solution was cooled at 0° C. with an ice bath. A solution of BH3 (1M in THF, 3.39 mL, 3.39 mmol) was added dropwise and the reaction was allowed to reach rt overnight. The mixture was quenched with NH4Cl (sat. solution, 2 mL) and diluted with ethyl acetate (20 mL). The organics were separated, washed with water (10 mL) and brine (10 mL) and dried over Na2SO4. The filtered solution was evaporated under vacuum to give (2-methyl-3-morpholinophenyl)methanol as a crude oil which crystallized over 2 h (0.5 g, quantitative).

후처리

  1. customThe mixture was quenched with NH4Cl (sat. solution, 2 mL)
  2. additiondiluted with ethyl acetate (20 mL)
  3. customThe organics were separated
  4. washwashed with water (10 mL) and brine (10 mL)
  5. dry with materialdried over Na2SO4
  6. customThe filtered solution was evaporated under vacuum

출처 및 근거

ORD 기록
ord-f047ba796cbd4cbfafe3a0c778ee1b84
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242987B2

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