Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichloroethane → (5-Chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | 6-(((Tert-butoxy)carbonyl)(ethyl)amino)pyridine-3-carboxylic acid | HCID 66769552 | — |
| 생성물 | (5-Chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester | HCID 86664610 | — |
반응 단계
6-(tert-Butoxycarbonyl-ethyl-amino)-nicotinic acid (6.40 g, 24.0 mmol) is taken up in 150 mL DCE, 1-chloro-N,N-2-trimethylpropenyl-amine (6.42 mL, 48.1 mmol) is added and the reaction mixture is stirred overnight at RT. The reaction mixture is concentrated under reduced pressure and the crude product is used in the next step without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09243000B2 |
| 출처 데이터셋 | uspto-grants-2016_01 |
| ORD ID | ord-068c5445f3374fb9b532cbba1e893995 |
| 출처 메모 | uspto-grants-2016_01 |