5-(3,6-dihydro-2H-thiopyran-4-yl)pyridin-2-amine → 5-(tetrahydro-2H-thiopyran-4-yl)pyridin-2-amine
반응식
[S:1]1[CH2:6][CH:5]=[C:4]([C:7]2[CH:8]=[CH:9][C:10]([NH2:13])=[N:11][CH:12]=2)[CH2:3][CH2:2]1>CO.C(Cl)Cl.[Pd]>[S:1]1[CH2:2][CH2:3][CH:4]([C:7]2[CH:8]=[CH:9][C:10]([NH2:13])=[N:11][CH:12]=2)[CH2:5][CH2:6]1참가 물질
5
실험 절차
A suspension of 5-(3,6-dihydro-2H-thiopyran-4-yl)pyridin-2-amine (260 mg, 1.35 mmol), Pd/C (36 mg, 0.33 mmol) in methanol (16 mL) was stirred under hydrogen at ambient temperature for 16 h. The reaction mixture was diluted with DCM (80 mL), and was filtered through Celite. The filtrate was concentrated to give 5-(tetrahydro-2H-thiopyran-4-yl)pyridin-2-amine (240 mg, 91% yield) as yellow color solid. LCMS (m/z): 195 (MH+), 0.46 min.
후처리
- filtrationwas filtered through Celite
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-4a23599ccaad4baab79178c67865d0b2
- 출처 데이터셋
- uspto-grants-2016_01
- 특허 번호
- US09242996B2
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