Trifluoroacetic acid → 3-Bromo-5-(pyrrolidin-3-yl)pyridin-2-amine

HRID 595818노트

반응식

HRID 595818 반응식
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)=[CH:4][C:3]=1[Br:20].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:20][C:3]1[C:2]([NH2:1])=[N:7][CH:6]=[C:5]([CH:8]2[CH2:12][CH2:11][NH:10][CH2:9]2)[CH:4]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 118045605Tert-butyl 3-(6-amino-5-bromopyridin-3-yl)pyrrolidine-1-carboxylate

생성물 1

HCID 1180452883-Bromo-5-(pyrrolidin-3-yl)pyridin-2-amine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To tert-butyl 3-(6-amino-5-bromopyridin-3-yl)pyrrolidine-1-carboxylate (65 mg, 0.171 mmol) in DCM (2.4 mL) was added TFA (0.6 mL, 7.79 mmol). The reaction mixture was stirred at room temperature for 45 min. The reaction mixture was evaporated in vacuo after dilution with toluene. The crude product was used for next step without purification. The crude yield was quantitative. LCMS (m/z): 242.1/244.1 (MH+), 0.214 min.

후처리

  1. customThe reaction mixture was evaporated in vacuo after dilution with toluene
  2. customThe crude product was used for next step without purification
  3. customThe crude yield
  4. custom242.1/244.1 (MH+), 0.214 min.

출처 및 근거

ORD 기록
ord-04113b0eb5ad4b289d34ce7c7f3e1272
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242996B2

반응 노트

불러오는 중…