Acetonitrile → HCID 11032835, 화합물

HRID 595965노트

반응식

HRID 595965 반응식
[NH2:1][C@@H:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:3][OH:4].C(#N)C.[C:14](ON1C(=O)CCC1=O)(=[O:25])[C:15]1[C:16](=[CH:21][CH:22]=[CH:23][CH:24]=1)[C:17](OC)=[O:18]>O>[OH:4][CH2:3][C@@H:2]([N:1]1[C:17](=[O:18])[C:16]2[C:15](=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]1=[O:25])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

5

반응물 3

HCID 6342AcetonitrileHCID 1347972-Amino-2-phenylethan-1-olHCID 10901878Methyl 2-[(succinimidooxy)carbonyl]benzoate

생성물 1

HCID 11032835HCID 11032835, 화합물수율 40%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of (S)-2-amino-2-phenylethanol (3 g, 21.87 mmol) in water (26.5 mL), and acetonitrile (46.4 mL) was added 2,5-dioxopyrrolidin-1-yl methyl phthalate (5.76 g, 20.78 mmol) at room temperature. The reaction mixture was stirred at room temperature for overnight. After acetonitrile was removed in vacuo, the reaction mixture was then extracted with EtOAc. The organic was washed by water and brine, dried over anhydrous sodium sulfate, filtered off, and concentrated in vacuo yielding (S)-2-(2-hydroxy-1-phenylethyl)isoindoline-1,3-dione (2.2 g, 40%). LCMS (m/z): 268 (MH+), 0.79 min.

후처리

  1. customAfter acetonitrile was removed in vacuo
  2. extractionthe reaction mixture was then extracted with EtOAc
  3. washThe organic was washed by water and brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationfiltered off
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-eed24d4ce7e446cc9b2ad05dc5cb950b
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09242996B2

반응 노트

불러오는 중…