홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Trifluoroacetic acid → Trifluoroacetic acid

HRID 596125
노트
인쇄 미리보기

반응식

HRID 596125 반응식
[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([C:14]([O:16]C(C)(C)C)=[O:15])=[C:10]([F:21])[CH:9]=1.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]>C(Cl)Cl>[NH2:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[C:10]([F:21])[CH:9]=2)=[N:6][C:5]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:4][N:3]=1.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 118045523Ethyl 5-amino-6-(4-(tert-butoxycarbonyl)-3-fluorophenyl)pyrazine-2-carboxylate

생성물 2

HCID 6422Trifluoroacetic acidHCID 1180454784-(3-Amino-6-(ethoxycarbonyl)pyrazin-2-yl)-2-fluorobenzoic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of ethyl 5-amino-6-(4-(tert-butoxycarbonyl)-3-fluorophenyl)pyrazine-2-carboxylate (0.253 g, 0.7 mmol) in DCM (4 mL) at RT was added TFA (2.157 mL, 28.0 mmol). The resultant solution was stirred at RT for 2 hours. The reaction solution was concentrated and further dried to afford the crude desired product as a TFA salt. This product was directly used at the next step. 0.214 g (100% yield) of light sticky liquid was obtained. LC-MS (m/z): 306.1 (MH+), 0.563 min.

후처리

  1. concentrationThe reaction solution was concentrated
  2. customfurther dried

출처 및 근거

ORD 기록
ord-0c47be53fa834000a1fc0252da94384e
출처 데이터셋
uspto-grants-2016_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09242996B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트