Potassium hydroxide ethanol → 5-Bromo-2-(7-bromo-9,9'-Dioctyl-9H-fluoren-2-yl)benzoic acid

HRID 596137노트

반응식

HRID 596137 반응식
C[O:2][C:3](=[O:41])[C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[CH:6][C:5]=1[C:11]1[CH:23]=[CH:22][C:21]2[C:20]3[C:15](=[CH:16][C:17]([Br:24])=[CH:18][CH:19]=3)[C:14]([CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[C:13]=2[CH:12]=1.[OH-].[K+].C(O)C>C(O)C>[Br:10][C:8]1[CH:7]=[CH:6][C:5]([C:11]2[CH:23]=[CH:22][C:21]3[C:20]4[C:15](=[CH:16][C:17]([Br:24])=[CH:18][CH:19]=4)[C:14]([CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[C:13]=3[CH:12]=2)=[C:4]([CH:9]=1)[C:3]([OH:41])=[O:2]

참가 물질

4

반응물 2

HCID 21946426Potassium hydroxide ethanolHCID 867235505-Bromo-2-(7-bromo-9,9'-Dioctyl-9H-fluoren-2-yl)benzoic acid methyl ester

생성물 1

HCID 586075385-Bromo-2-(7-bromo-9,9'-Dioctyl-9H-fluoren-2-yl)benzoic acid수율 102.3%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

35 g (51.2 mmol) 16 is suspended in 300 ml ethanol and treated with 50 ml 50% KOH/ethanol solution and heated to reflux for 3 h. After cooling to room temperature with reaction mixture is diluted with 200 ml ethanol, with precipitation is collected by filtration, the residue is washed with ethanol and dried in vacuum. 35 g (yield: 98%) of a white solid can be obtained.

후처리

  1. temperatureheated
  2. temperatureto reflux for 3 h
  3. filtrationis collected by filtration
  4. washthe residue is washed with ethanol
  5. customdried in vacuum

출처 및 근거

ORD 기록
ord-563a2223e3b2475a85831acdb2feaa2f
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09246103B2

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