Sodium Iodide → N-2-ethyl-cyclohexylamino-3,4,5-trimethoxy-benzoate-hydrochloride

HRID 596235노트

반응식

HRID 596235 반응식
[Na].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([O:15][CH3:16])[C:12]=1[O:13][CH3:14])[C:7]([O-:9])=[O:8].Cl.[Cl:18][CH2:19][CH2:20][NH:21][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1.[I-].[Na+]>CN(C)C=O>[ClH:18].[CH3:19][CH2:20][N:21]([C:10]1[C:11]([O:15][CH3:16])=[C:12]([O:13][CH3:14])[C:4]([O:3][CH3:2])=[CH:5][C:6]=1[C:7]([OH:9])=[O:8])[CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

참가 물질

5

반응물 3

HCID 5238Sodium IodideHCID 13756691N-(2-chloroethyl)cyclohexanamine hydrochlorideHCID 86734526Sodium 3,4,5-trimethoxy-benzoate

생성물 1

HCID 88821243N-2-ethyl-cyclohexylamino-3,4,5-trimethoxy-benzoate-hydrochloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 1.7 g. of sodium-3,4,5-trimethoxy-benzoate 1.45 g. of N-2-chloroethyl-cyclohexylamine hydrochloride and some sodium iodide crystals are added, whereafter 30 ml. of dimethyl formamide are introduced. After cooling toe precipitated crystals are filtered and the filtrate is evaporated. The residue is recrystallized from 96% of ethanol under clarifying with activated charcoal. Thus N-2-ethyl-cyclohexylamino-3,4,5-trimethoxy-benzoate-hydrochloride is obtained. M.p.: 208°-210° C.

후처리

  1. temperatureAfter cooling toe
  2. customprecipitated crystals
  3. filtrationare filtered
  4. customthe filtrate is evaporated
  5. customThe residue is recrystallized from 96% of ethanol

출처 및 근거

ORD 기록
ord-eaf5569218344429b65035dc5a7984e5
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04010193

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