Cyclopropanemethanamine, N-propyl- → HCID 21450829, 화합물

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15]Cl)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[C:22]([F:23])=[CH:21][CH:20]=[CH:19][C:18]=3[F:24])[C:6]=2[CH:25]=1.[CH2:26]([NH:29][CH2:30][CH:31]1[CH2:33][CH2:32]1)[CH2:27][CH3:28]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][N:29]([CH2:30][CH:31]4[CH2:33][CH2:32]4)[CH2:26][CH2:27][CH3:28])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[C:18]([F:24])=[CH:19][CH:20]=[CH:21][C:22]=3[F:23])[C:6]=2[CH:25]=1

참가 물질

반응물 2

HCID 117787Cyclopropanemethanamine, N-propyl-

HCID 20291813HCID 20291813, 화합물

생성물 1

HCID 21450829HCID 21450829, 화합물

실험 절차

In the manner given in Preparation 29, 8-chloro-1-(chloromethyl)-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is treated with propyl(cyclopropylmethyl)amine to give 8-chloro-1-[[(cyclopropylmethyl)propylamino]methyl]-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine. Preparation 34 8-Nitro-1-[[(cyclopropylmethyl)propylamino]methyl]-6-phenyl-4-H-s-triazolo[4,3-a][1,4]-benzodiazepine

출처 및 근거

ORD 기록: ord-de28600f52ff4c8a97cebf584e83cf4f
출처 데이터셋: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04010177

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