HCID 12674605, 화합물 → 2-Imidazolidinone, 1-(3-chlorophenyl)-3-(2-(3,3-dipropyl-1-azetidinyl)-1-methylethyl)-4-methyl-

HRID 596464노트

반응식

HRID 596464 반응식
Cl[CH2:2][CH:3]([N:5]1[CH:9]([CH3:10])[CH2:8][N:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[C:6]1=[O:18])[CH3:4].[CH2:19]([C:22]1([CH2:26][CH2:27][CH3:28])[CH2:25][NH:24][CH2:23]1)[CH2:20][CH3:21]>C1C=CC=CC=1>[Cl:17][C:13]1[CH:12]=[C:11]([N:7]2[CH2:8][CH:9]([CH3:10])[N:5]([CH:3]([CH3:4])[CH2:2][N:24]3[CH2:25][C:22]([CH2:26][CH2:27][CH3:28])([CH2:19][CH2:20][CH3:21])[CH2:23]3)[C:6]2=[O:18])[CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 12674605HCID 12674605, 화합물HCID 12674606HCID 12674606, 화합물

생성물 1

HCID 30402912-Imidazolidinone, 1-(3-chlorophenyl)-3-(2-(3,3-dipropyl-1-azetidinyl)-1-methylethyl)-4-methyl-

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A mixture of 7 g. of 3-(2-chloro-1-methylethyl)-1-(m-chlorophenyl)-4-methyl-2-imidazolidinone and 10 g. of 3,3-dipropylazetidine in 100 ml. of anhydrous benzene is heated in a bomb at 150°-160° C. for 8 hours. The solvent is evaporated under vacuum and the residue is taken up with water, alkalinized with aqueous sodium carbonate and extracted with diethyl ether. The residue obtained by evaporation of the organic layer is purified by column chromatography through silica gel, using as the eluent chloroform containing 8% of methanol. Yield 8.6 g., b.p. 220° C./0.5 mm Hg.

후처리

  1. additionA mixture of 7 g
  2. customThe solvent is evaporated under vacuum
  3. extractionextracted with diethyl ether
  4. customThe residue obtained by evaporation of the organic layer
  5. customis purified by column chromatography through silica gel

출처 및 근거

ORD 기록
ord-052635ad402b40818815f6a1da4f7caa
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04011238

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