Ammonia → 5,6,7,8-Tetrahydroquinoline-8-carboxamide
반응식
C[O:2][C:3]([CH:5]1[C:14]2[N:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH2:8][CH2:7][CH2:6]1)=O.[NH3:15]>CO>[N:13]1[C:14]2[CH:5]([C:3]([NH2:15])=[O:2])[CH2:6][CH2:7][CH2:8][C:9]=2[CH:10]=[CH:11][CH:12]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
Methyl-5,6,7,8-tetrahydroquinoline-8-carboxylate (9 g.) was dissolved in methanol previously saturated with ammonia (270 ml.) and heated in a bomb at 100° C for 5 days. The solvent was removed and the residual oil triturated with hot petroleum ether (40°-60°). The resultant solid was filtered and then recrystallised from ethylacetate giving the title compound as colourless needles mpt. 132° C (5 g.). Found: C, 67.7; H, 7.1; N, 16.0%. C10H12N2O requires: C, 68.1; H, 6.9; N, 15.9%.
후처리
- customThe solvent was removed
- customthe residual oil triturated with hot petroleum ether (40°-60°)
- filtrationThe resultant solid was filtered
- customrecrystallised from ethylacetate giving the title compound as colourless needles mpt
- custom132° C (5 g.)
출처 및 근거
- ORD 기록
- ord-f7cedcb7d4b84d1e992a2df768d64890
- 출처 데이터셋
- uspto-grants-1977_03
- 특허 번호
- US04011225
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