Methyl isothiocyanate → Thiourea, N-(2,6-dichlorophenyl)-N'-methyl-

HRID 596650노트

반응식

HRID 596650 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:3]=1[NH2:4].[CH3:10][N:11]=[C:12]=[S:13]>C(O)C>[CH3:10][NH:11][C:12]([NH:4][C:3]1[C:2]([Cl:1])=[CH:8][CH:7]=[CH:6][C:5]=1[Cl:9])=[S:13]

참가 물질

4

반응물 2

HCID 11167Methyl isothiocyanateHCID 118462,6-Dichloroaniline

생성물 1

HCID 7942238Thiourea, N-(2,6-dichlorophenyl)-N'-methyl-

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

130 g of 2,6-dichloro-aniline, 100 g of methyl isothiocyanate and 300 ml of 95% ethanol are refluxed during 14 hours, with stirring. The resulting solution is cooled in the freezer: the white solid formed is filtered and washed with isopropyl oxide. After recrystallization from isopropanol, 65 g of product (III : R = CH3), m.p. = 184° C, are collected.

후처리

  1. temperatureThe resulting solution is cooled in the freezer
  2. customthe white solid formed
  3. filtrationis filtered
  4. washwashed with isopropyl oxide
  5. customAfter recrystallization from isopropanol, 65 g of product (III : R = CH3), m.p. = 184° C
  6. customare collected

출처 및 근거

ORD 기록
ord-3971929cc6e24d77b53f34cdb3ed7ad5
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04011342

반응 노트

불러오는 중…