Water → L-methionyl-L-aspartyl-D-alanine amide hydrochloride

HRID 596804노트

반응식

HRID 596804 반응식
C(OC([NH:8][C@H:9]([C:14]([NH:16][C@H:17]([C:22]([NH:24][C@@H:25]([C:27]([NH2:29])=[O:28])[CH3:26])=[O:23])[CH2:18][C:19](=[O:21])[OH:20])=[O:15])[CH2:10][CH2:11][S:12][CH3:13])=O)(C)(C)C.O.[ClH:31].O1CCOCC1>C(O)(=O)C>[ClH:31].[NH2:8][C@H:9]([C:14]([NH:16][C@H:17]([C:22]([NH:24][C@@H:25]([C:27]([NH2:29])=[O:28])[CH3:26])=[O:23])[CH2:18][C:19](=[O:20])[OH:21])=[O:15])[CH2:10][CH2:11][S:12][CH3:13]

참가 물질

5

반응물 3

HCID 962WaterHCID 204431481,4-Dioxane hydrochlorideHCID 22796339N-t-butoxycarbonyl-L-methionyl-L-aspartyl-D-alanine amide

생성물 1

HCID 22796354L-methionyl-L-aspartyl-D-alanine amide hydrochloride

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

12.54 Parts of N-t-butoxycarbonyl-L-methionyl-L-aspartyl-D-alanine amide is dissolved in 107 parts by volume glacial acetic acid and 51.66 parts by volume of a 5.6 M solution of HCl/dioxane. The resultant mixture is stirred for 20 minutes and then stripped under reduced pressure to afford a solid. The solid is triturated with ethyl ether, cooled, and the resultant product washed with cold ethyl ether and vacuum dried. This solid is purified by countercurrent distribution to afford L-methionyl-L-aspartyl-D-alanine amide hydrochloride hydrated with 2/3 mole of water per mole, and represented by the following formula.

후처리

  1. customto afford a solid
  2. customThe solid is triturated with ethyl ether
  3. temperaturecooled
  4. washthe resultant product washed with cold ethyl ether and vacuum
  5. customdried
  6. customThis solid is purified by countercurrent distribution

출처 및 근거

ORD 기록
ord-c6ddfcbe70fe4dab9a37bb9b849a37d2
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04012367

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