N-t-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-D-alanine amide → N-t-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-2-amino-2-methylpropionamide

HRID 596807

반응식

HRID 596807 반응식
Cl.[NH2:2][C@H:3]([C:8]([NH:10][C@H:11]([C:16]([CH2:18][C:19]([NH2:24])([CH3:23])[C:20]([NH2:22])=[O:21])=[O:17])[CH2:12][C:13](=[O:15])[OH:14])=[O:9])[CH2:4][CH2:5][S:6][CH3:7].[C:25]([O:29][C:30]([NH:32][C@H:33]([C:44](N[C@H](C(N[C@H](C(N[C@@H](C(N)=O)C)=O)CC(=O)O)=O)CCSC)=[O:45])[CH2:34][C:35]1[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[NH:37][CH:36]=1)=[O:31])([CH3:28])([CH3:27])[CH3:26]>O>[C:25]([O:29][C:30]([NH:32][C@H:33]([C:44]([NH:2][C@H:3]([C:8]([NH:10][C@H:11]([C:16]([CH2:18][C:19]([NH2:24])([CH3:23])[C:20]([NH2:22])=[O:21])=[O:17])[CH2:12][C:13](=[O:14])[OH:15])=[O:9])[CH2:4][CH2:5][S:6][CH3:7])=[O:45])[CH2:34][C:35]1[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[NH:37][CH:36]=1)=[O:31])([CH3:27])([CH3:28])[CH3:26]

참가 물질

4

반응물 2

HCID 22796331N-t-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-D-alanine amideHCID 131710666L-methionyl-L-aspartyl-2-amino-2-methylpropionamide hydrochloride

생성물 1

HCID 131710665N-t-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-2-amino-2-methylpropionamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

When an equivalent quantity of L-methionyl-L-aspartyl-2-amino-2-methylpropionamide hydrochloride is substituted for the L-methionyl-L-aspartyl-D-alanine amide hydrochloride of Example 6, and the procedure detailed therein substantially repeated, there is obtained N-t-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-2-amino-2-methylpropionamide containing 1/3 mole of water of hydration per mole. This compound is represented by the following formula. ##STR15##Elemental analysis of this compound shows C: 54.45%; H: 6.69%; N: 12.69% and S: 4.96%. Theory is C: 54.36%; H: 6.71%; N: 13.11% and S: 5.00%.

출처 및 근거

ORD 기록
ord-bf8b7d2b172a4c23b3ee148aaba75f04
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04012367

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