Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | N-benzyloxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide | HCID 22796407 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Ethyl methyl sulfide | HCID 12230 | — |
| 생성물 | L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide | HCID 22796390 | — |
반응 단계
N-benzyloxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide is dissolved in 10 parts glacial acetic acid containing 2 parts methylethyl sulfide. Then, 10 parts of 6 M hydrobromic acid in acetic acid is added and the solution is allowed to stand for one hour at room temperature. The solvents are removed under vacuum below 40° C. and the residue shaken with ether to afford L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide. This compound is represented by the following formula.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04012367 |
| 출처 데이터셋 | uspto-grants-1977_03 |
| ORD ID | ord-8ac2eeb5e3e447358b5e3ac14dbce5f5 |
| 출처 메모 | uspto-grants-1977_03 |