Triethylamine → HCID 21448606, 화합물

HRID 596871노트

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HRID 596871 반응식
Cl[C:2]([C:4]([CH2:11][CH3:12])([CH2:9][CH3:10])[C:5]([O:7][CH3:8])=[O:6])=[O:3].C(N(CC)CC)C.[CH3:20][O:21][C:22](=[O:27])[CH2:23][CH2:24][NH:25][CH3:26]>CCOCC>[CH2:9]([C:4]([CH2:11][CH3:12])([C:2](=[O:3])[N:25]([CH3:26])[CH2:24][CH2:23][C:22]([O:21][CH3:20])=[O:27])[C:5]([O:7][CH3:8])=[O:6])[CH3:10]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 12414198Methyl N-methyl-beta-alaninateHCID 21448656HCID 21448656, 화합물

생성물 1

HCID 21448606HCID 21448606, 화합물수율 93%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

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온도
-10 °C

실험 절차

To a solution of 19.2 g of methyl 2-chloroformyl-2-ethyl-butyrate and 20 g of triethylamine in 100 ml of dry ether, which is mechanically stirred and cooled at -10° C, there is added dropwise 12.8 g of N-methyl-β-alanine methyl ester dissolved in 50 ml of dry ether. After the addition, which takes 30 minutes, the mixture is stirred during 18 hours at room temperature. After filtration of the separated triethylamine hydrochloride, the solvent is evaporated leaving the desired product as an oil, boiling at 118° C (0.2 mm). Yield 93%. nD19 1.4646.

후처리

  1. additionAfter the addition, which
  2. filtrationAfter filtration of the separated triethylamine hydrochloride
  3. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-9b25783c665246b386d839daaff9011c
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04012392

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