Trifluoroacetic acid → 5-Chloro-2-(methylsulfanyl)-1-benzofuran-3(2H)-one

HRID 596905노트

반응식

HRID 596905 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([C:8](=[O:13])[CH2:9][S:10]([CH3:12])=O)[CH:7]=1.FC(F)(F)C(O)=O>C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:14][CH:9]([S:10][CH3:12])[C:8](=[O:13])[C:6]=2[CH:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 218282501-(5-Chloro-2-hydroxyphenyl)-2-(methanesulfinyl)ethan-1-one

생성물 1

HCID 214145205-Chloro-2-(methylsulfanyl)-1-benzofuran-3(2H)-one

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

5-Chloro-2-hydroxy-1-[(methylsulfinyl)acetyl]benzene (6.0 g) and trifluoroacetic acid (6 g) are refluxed in benzene (50 ml) for one hour under nitrogen. The solvent is removed under reduced pressure to give a yellow oil, which crystallizes on standing. Recrystallization from ethanol gives white crystals. (3.0 g 54%) m.p. 76°-78° C.

후처리

  1. customThe solvent is removed under reduced pressure
  2. customto give a yellow oil, which
  3. customcrystallizes
  4. customRecrystallization from ethanol
  5. customgives white crystals

출처 및 근거

ORD 기록
ord-ba608b646d1049cbb2ebcba62c334e9e
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04012422

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