Potassium Iodide → (1-Oxo-2-ethyl-6,7-dichloro-5-indanyloxy)acetonitrile

HRID 597014노트

반응식

HRID 597014 반응식
[CH2:1]([CH:3]1[CH2:11][C:10]2[C:5](=[C:6]([Cl:14])[C:7]([Cl:13])=[C:8]([OH:12])[CH:9]=2)[C:4]1=[O:15])[CH3:2].C(=O)([O-])[O-].[K+].[K+].Cl[CH2:23][C:24]#[N:25].[I-].[K+]>CC(C)=O>[O:15]=[C:4]1[C:5]2[C:10](=[CH:9][C:8]([O:12][CH2:23][C:24]#[N:25])=[C:7]([Cl:13])[C:6]=2[Cl:14])[CH2:11][CH:3]1[CH2:1][CH3:2]

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 7856ChloroacetonitrileHCID 11430Potassium CarbonateHCID 128572202-Ethyl-5-hydroxy-6,7-dichloroindanone

생성물 1

HCID 12395624(1-Oxo-2-ethyl-6,7-dichloro-5-indanyloxy)acetonitrile

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 2-ethyl-5-hydroxy-6,7-dichloroindanone (24.5 g., 0.1 mole), anhydrous potassium carbonate (13.8 g., 0.10 mole), chloroacetonitrile (7.55 g., 0.10 mole) and potassium iodide (1.66 g.) in acetone (0.5 l.) is refluxed for 18 hours. The product which precipitates upon addition of water to the reaction mixture (20 g., 71%) melts at 139°-141° C. after recrystallization from butyl chloride.

후처리

  1. temperatureis refluxed for 18 hours
  2. customThe product which precipitates upon addition of water to the reaction mixture (20 g., 71%) melts at 139°-141° C.
  3. customafter recrystallization from butyl chloride

출처 및 근거

ORD 기록
ord-2a35404037ff4b7db820cc8e602d7865
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04012524

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