1-Cyclopropylpiperidin-4-one → 8-Cyclopropyl-1,2,7,8,9,10-hexahydropyrido[3',4':4,5]pyrrolo[1,2,3-de][1,4]benzoxazine hydrochloride

반응식

[ClH:1].N[N:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][CH2:5][CH2:4]1.[CH:13]1([N:16]2[CH2:21][CH2:20][C:19](=O)[CH2:18][CH2:17]2)[CH2:15][CH2:14]1>>[ClH:1].[CH:13]1([N:16]2[CH2:21][CH2:20][C:19]3[N:3]4[C:8]5[C:9](=[CH:10][CH:11]=[CH:12][C:7]=5[O:6][CH2:5][CH2:4]4)[C:18]=3[CH2:17]2)[CH2:15][CH2:14]1

참가 물질

반응물 2

HCID 162276291-Cyclopropylpiperidin-4-one

HCID 224889852H-benzo[b][1,4]oxazin-4(3H)-amine hydrochloride

생성물 1

HCID 203047758-Cyclopropyl-1,2,7,8,9,10-hexahydropyrido[3',4':4,5]pyrrolo[1,2,3-de][1,4]benzoxazine hydrochloride

실험 절차

4-Amino-3,4-dihydro-2H-1,4-benzoxazine hydrochloride is reacted with 1-cyclopropyl-4-piperidone according to the procedure of Example 110 to yield the title compound, m.p. 232°-233° .

출처 및 근거

ORD 기록: ord-c83440ad900b457dba00daab5b046f91
출처 데이터셋: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04013652

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